Asso. Professor - Stage II & Director (LCRI)
M.Sc, Ph.D, CSIR-UGC-NET
Dr. Asha Abraham, has been with the department since its inception in 2002. She earned her PhD from Cochin University of Science and Technology in 1999 and pursued postdoctoral research at the College of Fisheries, Mangalore. Her research focuses on metabolic disorders, neuroendocrinology, phytomedicine, and immunology.
She has successfully led research projects worth ₹60 lakhs, funded by BRNS, UGC, VGST and MJES, and is currently coordinating a ₹2.202 crore DBT-BUILDER interdisciplinary project. Her work on adrenergic receptors in diabetes and obesity was featured in The Telegraph https://www.telegraphindia.com/india/rat-model-to-study-metabolic-syndrome/cid/1510741, The Wire (https://science.thewire.in/science/animal-biologist-special-diet-plan-mice/) and The Hindu https://www.thehindu.com/education/metabolic-mysteries/article24239438.ece . She has also explored natural compounds for their anti-tumor, anti-adipogenic, and anti-diabetic properties.
Dr. Abraham has successfully guided six PhD scholars and supervised 75 MSc research projects. She has published 35 peer-reviewed research papers, coauthored 84 conference papers, contributed three book chapters, and co-authored two textbooks. Her research impact includes 241 Scopus citations (h-index: 6) and 474 Google Scholar citations (h-index: 9).
She received the Erasmus+ Staff Mobility Fellowship (2022) for training in Valencia, Spain, and conducted collaborative cognitive neuroscience research at Sophia University, Tokyo, in 2018. A life member of several scientific societies, she has also organized numerous national and international seminars.
Sl.No | Qualification Level | University | Area of Specialization | Year of Completion | Awards |
---|---|---|---|---|---|
1 | PhD | Cochin University of Science and Technology, Kochi | Biotechnology ( Cellular and Molecular Neurobiology) | 1999 | CSIR JRF & SRF Cleared course work with distinction 1993. |
2 | MSc | Cochin University of Science and Technology, Kochi | Biotechnology | 1992 | Univeristy Merit Scholarship 1990-1992 Ranked 1 st in University with distinction Jawaharlal Nehru Memorial Fund award (New Delhi) for securing First rank in the M.Sc. Biotechnology
|
3 | BSc | St Teresas’s College Ernakulam, Mahatma Gandhi University, Kottayam, Kerala | B.Sc. Zoology (main), Botany & Chemistry (Subsidiary) | 1989 | University Merit scholarship 1986-1989 Ranked first in College with distinction |
Director Loyola Centre for Research and Innovation
Chairperson Institutional Animal ethics Committee (appointed by Committee for Control and Supervision of Experiments on Animals (CCSEA) a statutory Committee of Department of Animal Husbandry and Dairying (DAHD), Ministry of Fisheries, Animal Husbandry and Dairying (MoFAH&D), GoI
DBT BUILDER project coordinator
Associate Professor
PhD guide
Member of the Executive Council of the Deemed to be University (2025-2026)
Member of the Academic Council of the Deemed to be University
Member of Academic Council of Autonomous College
Member of Staff council
Member of IQAC
Member of Research and Development Cell
Member of Anti Ragging & Anti -Drug abuse committee
Member Academic formation of staff
2024 March - |
Director LCRI, Associate Professor |
2010- till date |
Associate Professor Department of Post Graduate Studies and Research in Biotechnology, St. Aloysius College (Autonomous), Mangalore 575 003, Karnataka, India |
2002-2010 |
Assistant Professor Department of Post Graduate Studies and Research in Biotechnology, St. Aloysius College (Autonomous), Mangalore 575 003, Karnataka, India |
2000-2002 |
Research Associate CSIR, Department of Aquaculture, College of Fisheries, Mangaluru, Karnataka, India |
1997-1999 |
Senior Research Fellow CSIR, Department of Biotechnology, Cochin University of Science and Technology, Kochi, Kerala, India |
1993-1996 |
Lecturer in Zoology, C.M.S. College, Kottayam, M.G. University, Kerala India. |
1992-1993 |
Junior Research Fellow CSIR, Department of Biotechnology, Cochin University of Science and Technology, Kochi, Kerala, India |
Molecular and cellular aspects of Metabolic syndrome, Hypothyroidism, Diabetes and Cancer,
Phytomedicine
Immunology
Neuroendocrinology of aging
Selected research papers
Selected conference papers
Title of the Project |
Amount INR |
Current Status |
|
DBT, GoI |
DBT-BUILDER – St Aloysius College (Autonomous) Interdisciplinary Life Science Programme for Advance Research and Education Bioprospecting of marine macroalgae for value added products from the Dakshina Kannada- Udupi coast.-Project Coordinator |
2,20,51,560 /- |
Ongoing 2022-2027 |
MJES-SAC |
Analysis of Beta-3-Adrenergic Receptors on the Pancreatic Islet Beta Cells of High Fat Simple Carbohydrate fed male C57BL/6J mice: Implications in Metabolic Syndrome. Intra mural seed money for research Priniple Investigator |
6,00,000/- |
Completed 2019-22 |
VGST. GoK |
Identification of Adrenergic receptor subtype involved in Metabolic syndrome: A futuristic therapeutic target -- Research fund for Talented teachers (RFTT) Principle Investigator |
Rs 5,00,000/- |
Completed 2018-2019 |
UGC |
Evaluate the role of Norepinephrine in Leptin production and secretion in vitro Minor Project Principle Investigator |
Rs.4,00,000/- |
Completed 2015-2017 |
BRNS |
Adrenergic Receptor Subtype Functional Correlation In the Brain and Pancreas of High Fat Simple Carbohydrate Fed C57BL/6J Mice: Implications In Metabolic Syndrome Major Project Principle Investigator |
Rs.31,75,145/- |
Completed 2013-2017 |
UGC |
Elucidation of the role of Leptin in the regulation of the hypothalamus-pituitary-adrenal axis in metabolic syndrome Major Project Principle Investigator |
Rs.10,96,500/- |
Completed 2011-2014 |
UGC |
Evaluation of the anti tumor effect of Garcinia cambogia in vivo Minor Project Principle Investigator |
Rs.40,000/- |
Completed 2008-2010. |
UGC |
Evaluation of the anti diabetic effect of ‘Insulin plant’ Minor Project Principle Investigator |
Rs.1,00,000/- |
Completed 2005-2007. |
Student-Teacher projects:
Funding Agency |
Title of the Project & Name of students |
Amount INR |
Current Status |
Karnataka state council for science and technology, IISc campus, Bengaluru |
Formulation of a seaweed-derived larvicide with mosquito attractant properties for targeted vector control Under 48th series of student project programme Anjishnu Mukhopadhya Gourav Nandkishore Desai Fathima Rida |
5,500/- |
Ongoing 2024-25 |
MJES |
Isolation, Production and Purification of Laccase from Soil Microbes and its Applications Diya Bangera Monika Malatesh Jadar Vinisha Crasta |
7500/- |
Ongoing 2024-25 |
MJES |
Study of expression of PPAR alpha, PPAR delta, PPAR gamma in metabolic syndrome induced mice. Ms Manasvi Ms Bhavya J N |
10,000/- |
Completed2019-20 |
MJES |
Gene expression analysis of thyroid hormone receptors in the liver of metabolic syndrome induced mice. Ms Shreyoshree Mukherjee |
10,000/- |
Completed2019-20 |
MJES |
Analysis of β -adrenergic receptor subtypes in the liver of metabolic syndrome induced C57BL/6J mice Aravind Nayaka H A Deekshith K |
7,500/- |
Completed 2021-22 |
MJES
|
Study of effect of Juglans regia on Metabolic Syndrome induced C57BL/6J mice and evaluation of its molecular mechanism Smruthi Prabhu |
5000/- |
Completed 2014-15 |
FELLOWSHIPS, AWARDS & SCHOLARSHIPS
Father George Albuquerque Pai Cell and Molecular Biology Laboratory
A laboratory under the recognized research Centre in Biotechnology of Mangalore University
Thrust areas: Cellular and Molecular aspects of metabolic syndrome, diabetes & cancer
Dr Asha Abraham -Team Lead
Dr Abraham’s Ph.D. work at CUSAT under the guidance of Late Professor Dr CS Paulose, was on studying the changes in adrenergic receptor subtypes and monoamines in the brain and pancreas and their role in insulin secretion as a function of age in Streptozotocin diabetic rats. She further pursued Post Doctoral Fellowship at College of Fisheries, Mangalore where she was involved in the development and characterization of Biofilm vaccines for carnivorous fishes. Based on her expertise, she availed several grants from UGC (minor and Major), BRNS, VGST and MJES which helped her set up a research group focussing on the molecular aspects of Metabolic syndrome which is clustering of type II diabetes, hypercholesterolemia and obesity.
The laboratory has developed an animal model for metabolic syndrome (MetS) by feeding with High Fat Simple Carbohydrate (HFSC) diet to male wistar rats and C57BL/6J mice for a period of five months. The model displayed MetS symptoms like impaired glucose tolerance, insulin resistance, hyperglycemia, dyslipidemia and hyperinsulinemia in addition to hypertrophy of pancreatic islets. Also studies indicated that the animal model developed symptoms of Non Alchoholic fatty liver disease (NAFLD) which is strongly associated with MetS.
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Ms Serena Stephan Donna D’Souza (CSIR-JRF& SRF 2010-2015), awarded PhD in Biotechnology by Mangalore University for her thesis “Molecular Studies on Metabolic syndrome” in June 2015. An alumna of MSc Biotechnology of the department, she was among the first set of PhD students to join the laboratory and her work has laid the foundation for the research conducted in the lab. She helped establish the animal model. She used HPLC system to extensively study neurotransmitters and their metabolites as well as ELISA to quantify insulin and leptin levels. Her work revealed that the Norepinephrine (NE) levels were high in the plasma and hypothalamus of the metabolic syndrome induced mice. The central and peripheral serotonergic pathway was also found to be affected differentially by both the type of diet consumed and the duration for which the diet is consumed. These findings may have implications in the feeding behavior, cognitive decline and depression associated with metabolic syndrome patients. She has presented her work in 15 conferences and published 8 research papers and contributed to 2 book chapters. Dr D’Souza is currently working as Faculty Research Associate at The Johns Hopkins University School of Medicine Baltimore, Maryland, United States. |
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Ms Neena Roy, (BRNS JRF &SRF 2013 -2020) continued the study by focussing on adrenergic receptor signalling pathways in the brain and pancreas and was awarded PhD by Mangalore University for her thesis “ Analysis of Adrenergic Receptors during the onset and progression of Metabolic Syndrome” on 7th January, 2020. She has performed radioreceptor assays, perfusion, immunohistochemistry and ELISA to study the recpetor ligand interaction and down stream signalling pathways. She has published 5 research papers and has 19 conference presentations to her credit. Notable was her presentation on "Adrenergic receptors: A possible target for Metabolic Syndrome" in the 41st European Symposium on Hormones and Cell Regulation: conference on ‘GPCR dynamics for fine tuning of physiological processes’ during October 5-8, 2016 at Mont Ste Odile, Strasbourg, France. Currently Dr Roy is a post doctoral fellow at College of Medicine and Health Sciences, United Arab Emirates University,Al Ain. |
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Ms Vijayalakshmi G Rao (Baterna Fellow 2018-2024), continued further on analysis of beta adrenergic receptor (βAR) expression in the pancreatic islets. Comprehensive investigations using real time PCR, western blott and Immunoflurescence techniques revealed significant alterations in the expression of β1, β2, and β3-ARs in response to dietary stress. Proteomic analysis of the pancreatic islets also pointed to the potential links to pancreatic cancer and other metabolic disorders. Ms Vijayalakshmi has published 5 research papers. She has presented her work in 14 conferences. Notable are her presentations on “A Proteomic Study of Pancreatic Islets in Metabolic Syndrome-Induced Mice: Unravelling Dysregulated Pathways” at EMBL–Wellcome Connecting Science Conference Proteomics in cell biology and disease mechanisms 25 - 27 Oct 2023 EMBL Heidelberg Germany, “Expression of beta 2 adrenergic receptors in the pancreatic islets of metabolic syndrome induced C57BL/6J mice” at 24th European Congress of Endocrinology, Milan, Italy on 21st May 2022 to 24th May 2022 and “ Effect of beta-adrenergic receptor agonists and antagonist on glucose induced insulin secretion in vitro” at the 9th GDR3545-GPCR international meeting held online from November 6th to 9th 2020. She has submitted her PhD thesis entitled “Study of the beta-adrenergic receptors in the pancreatic beta cells in metabolic syndrome induced male C57BL/6J mice” to Mangalore University and is awaiting her results. |
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Ms Swarnalatha BN (Part time researcher-2011-2018) Asst Professor at Dept of Biochemistry, further found that the Hypothalamus -pituitary thyroid axis signalling pathways were disrupted in HFSC fed mice. She was awarded PhD for her thesis “Elucidation of the molecular mechanisms of thyroid hormone secretion and action in metabolic syndrome” by Mangalore University on 27th September, 2018. She has published 3 research papers and has 5 conference presentations. Presently, Dr Swarnalatha is working as Associate Professor at Aloysius Deemed to be University. Ms Swarnalaltha availed UGC minor project to carry out this work. |
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Dr. Santhosh W Goveas (Part time researcher-2011-2018) Asst Professor Dept of Biotechnology, explored the anti diabetic effects of the medicinal plant Coscinium fenestratum in Streptozotocin induced diabetic rats and in cultured cells. He was awarded PhD by Mangalore University for his thesis entitled “In vitro and in vivo studies on the anti-diabetic properties of Coscinium fenestratum” on 5th May 2018. He has 2 conference presentations and 3 research publications from this work. Dr Goveas availed UGC minor grants to conduct this research. He is currently working as Assistant Professor stage -III at St Aloysius Deemed to be University. |
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Ms. Renita D’Souza ( Part time researcher 2011 – 2022) Asst Professor Dept of Biotechnology, worked on microbial Asparaginases and was awarded PhD by Mangalore University on 11th March 2022 for her thesis entilted “Isolation, Purification, Characterization and Evaluation of Cytotoxic Effect of L-Asparaginase”. She has 2 conference presentations and has published 3 research papers. Dr D’Souza availed UGC minor grants to conduct this research. She is currently working as Associate Professor stage II at St Aloysius Deemed to be University. |
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Mr. Sreejesh P.C. (Part time researcher-2015-2024) Asst Professor Dept of Biotechnology, pursued his research interests in exploiting the ovarian microbiomes for drug discovery against ovarian cancer. He was awarded PhD by Mangalore University on 29th October 2024 for his thesis entitled “Isolation Purification, Characterization of potential anti ovarian cancer drugs from microbial sources”. He has published 3 research papers and has 3 conference presentations to his credit. Dr Sreejesh has availed MJES seed grants for completing this work.
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Rev Fr Royston Madtha S.J. ( 2021-) is pursuing his doctoral studies at Mangalore University on Bio Prospecting of Pigment Producing Bacteria from The Estuaries of Netravathi River. Fr Madtha has 5 conference presentations to his credit. He is pursuing this work with MJES major project. |
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